| Date | Event |
| 1564 | Outbreak of plague in Leicester |
| 1579 | Outbreak of plague in Leicester |
| 1583 | Outbreak of plague in Leicester |
| 1593 | Outbreak of plague in Leicester |
| 1604 | Outbreak of plague in Leicester |
| 1606 | Outbreak of plague in Leicester |
| 1610 | Outbreak of plague in Leicester |
| 1625 | Outbreak of plague in Leicester |
| 1636 | Outbreak of plague in Leicester |
| 1638 | Outbreak of plague in Leicester |
| 1771 | Leicester Royal Infirmary opens |
| 1800 | Leicester Medical Book Society founded |
| 1816 | The Newtown Linford Sick Club has its HQ at 'Mr Kinton's, the sign of the Bradgate Arms' |
| 1849 | Epidemic of cholera in Leicester |
| 1904 | Carlton Hayes Hospital opened as Leicestershire and Rutland County Lunatic Asylum |
| 1927 | Measles epidemic at Newton Linford. School closed by Medical Officer |
| 1935 | Leicester General Hospital opens |